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RESEARCH PROJECTS

Some of our funded research on schizophrenia, autism, depression, and suicide is listed below.

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ABOUT THE PG LAB

We are a data science lab focused on psychiatric genomics and the prevention of serious mental illness.

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PARTICIPATE

Contact us to hear about RA opportunities. And we will begin research studies in Fall of 2018–please check back to stay informed.

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Current research

Genome-Wide Polygenic Risk Mapping Of The Phenome in Emerging Adulthood

This study examined genetic risk for numerous health and psychiatric phenotypes to predict real-world outcomes in a sample of emerging adults (N = 5,947) from multiple ancestries: http://www.biorxiv.org/content/early/2017/04/06/124651

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GWAS of Completed Suicide And Molecular Genetic Overlap Of Suicide, Psychosis, And Major Depression

Imputing genotype data in over 4,500 completed suicides in Utah, we are undertaking the first genome-wide association study of completed suicide. This study will calculate polygenic and methylation risk scores and examine polygenic overlap of suicide with major psychiatric and medical disorders.

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Polygenic And Rare Variant-Based Subtyping Of Autism Spectrum Disorders

This research will leverage whole-genome sequencing in a large sample of autism pedigrees to predict clinical phenotypes using rare variants and polygenic risk profiling.

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Molecular Subtyping Of Schizophrenia And Major Depression, Accounting For Sex And Population Stratification

Genetic sorting methods that use machine learning to predict risk may aide early diagnostic and intervention efforts.

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