SimPRS: Fast Simulation of Polygenic Risk Scores to estimate PRS performance under various conditions and p-value thresholds
Fast PRS simulations allow us to select an optimal p-value threshold γ, perform more accurate power analyses, and estimate the polygenicity of a phenotype.
It has become apparent that compiling data into a protected, relational database and crowdsourcing analytic and data science expertise will result in significant enhancement of current research on the structure and biological substrates of the psychosis spectrum.
Imputing genotype data from 4,800 completed suicide deaths and 3,500 ancestry-matched controls, we are able to conduct genome-wide association studies of completed suicide. These analyses also involve calculation of polygenic and methylation risk scores, and examine polygenic overlap of suicide w...
This research leverages whole-genome sequencing in a large sample of autism pedigrees to predict clinical phenotypes using rare variants and polygenic risk profiles.
This research maps genetic risk for numerous health and psychiatric phenotypes to real-world outcomes and behaviors in emerging adults (N = 5,947) across ancestries.
Pathway-based Polygenic Risk for Severe Depression Implicates Drug Metabolism in a Large Han Chinese Cohort
Using low-coverage whole genome sequencing in the CONVERGE cohort (N = 10,640), we derived polygenic risk scores specific to each of over 300 molecular pathways previously shown to be relevant to severe psychopathology. We then identified gene pathways significantly predictive of recurrent depres...