It has become apparent that compiling data into a protected, relational database and crowdsourcing analytic and data science expertise will result in significant enhancement of current research on the structure and biological substrates of the psychosis spectrum.
Using low-coverage whole genome sequencing in the CONVERGE cohort (N = 10,640), we derived polygenic risk scores specific to each of over 300 molecular pathways previously shown to be relevant to severe psychopathology. We then identified gene pathways significantly predictive …
Hilary Coon, Todd M. Darlington, W. Brandon Callor, Elliott Ferris, Alison Fraser, Zhe Yu, Nancy William, Sujan C. Das, Sheila E. Crowell, Megan Puzia, Michael Klein, Anna Docherty, Leslie Jerominski, Dale S. Cannon, Ken R. Smith, Brooks Keeshin, Amanda V. Bakian, Erik Christensen, Nicola J. Camp, Douglas Gray
Docherty AR, Edwards AC, Yang F, Peterson RE, Sawyers C, Adkins DE, Moore AA, Webb BT, Bacanu SA, Flint J, Kendler KS.
Docherty AR, Moscati AA, Fanous AH.
Edwards AC, Aggen SH, Cai N, Bigdeli TB, Peterson RE, Docherty AR, Webb BT, Bacanu SA, Flint J, Kendler KS.
Docherty AR, Sawyers CK, Panizzon MS, Neale MC, Eyler LT, Fennema-Notestine C, Franz CE, Chen CH, McEvoy LK, Verhulst B, Tsuang MT, Kremen WS.