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    16 May

    Enhancing Psychosis-Spectrum Nosology through an International Data Sharing Initiative

    • Posted by PG Lab Media
    • Categories CURRENT RESEARCH
    • Comments 0 comment

    It has become apparent that compiling data into a protected, relational database and crowdsourcing analytic and data science expertise will result in significant enhancement of current research on the structure and biological substrates of the psychosis spectrum. We’ve developed a …

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    16 May

    Pathway-based Polygenic Risk for Severe Depression Implicates Drug Metabolism in a Large Han Chinese Cohort

    • Posted by PG Lab Media
    • Categories CURRENT RESEARCH
    • Comments 0 comment

    Using low-coverage whole genome sequencing in the CONVERGE cohort (N = 10,640), we derived polygenic risk scores specific to each of over 300 molecular pathways previously shown to be relevant to severe psychopathology. We then identified gene pathways significantly predictive …

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    14 February

    Fast Simulation of Polygenic Risk Scores to Estimate PRS Performance under Various Conditions and Thresholds

    • Posted by PG Lab Media
    • Categories CURRENT RESEARCH
    • Comments 0 comment

    We’ve created an extremely efficient pipeline for imputation, QC, and processing of polygenic risk on a massive scale. Fast PRS simulations allow us to select an optimal p-value threshold γ, perform more accurate power analyses, and evaluate the polygenicity of a …

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    14 February

    Genome-Wide Polygenic Risk Mapping Of The Phenome in Emerging Adulthood

    • Posted by PG Lab Media
    • Categories CURRENT RESEARCH
    • Comments 0 comment

    This research maps genetic risk for numerous health and psychiatric phenotypes to real-world outcomes and behaviors in emerging adults (N = 5,947) across ancestries.

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    14 February

    First Comprehensive Genome-Wide Association Study of Suicide Death

    • Posted by PG Lab Media
    • Categories CURRENT RESEARCH
    • Comments 0 comment

    Imputing genotype data from 4,800 suicide deaths in Utah and 14,810 ancestry-matched controls, we were able to conduct the first major genome-wide association study of suicide death. These analyses included calculation of polygenic risk scores and examined polygenic overlap of …

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    14 February

    Simons Foundation Award: Polygenic And Rare Variant-Based Genetic Subtyping Of Autism Spectrum Disorders

    • Posted by PG Lab Media
    • Categories CURRENT RESEARCH
    • Comments 0 comment

    This research leverages whole-genome sequencing in a large sample of autism pedigrees to predict clinical phenotypes using rare variants and polygenic risk profiles.

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    Recent Tweets

    Dr. Anna DochertyFollow

    Assistant Professor, Psychiatry psychiatric genetics, suicide, schizophrenia, psychopathology, clinical prediction of risk & resilience

    Dr. Anna Docherty
    Retweet on TwitterDr. Anna Docherty Retweeted
    caina89Na Cai@caina89·
    13 Dec

    I’m hiring postdocs for my new lab in ⁦@PioneerCampus⁩⁩! Join me in studying #genetics of #depression and involvement of #mtDNA in stress and disease - together we can find the metabolic link to mental health conditions. Please RT! https://bit.ly/2Eds11M

    Reply on Twitter 1205286365845323776Retweet on Twitter 120528636584532377661Like on Twitter 120528636584532377663Twitter 1205286365845323776
    Retweet on TwitterDr. Anna Docherty Retweeted
    DPosthuDanielle@DPosthu·
    12 Dec

    We still have positions for postdocs with a background in Statistical Genetics or Bioinformatics to work on several exciting projects concerning stat gen methods' development and optimizing GWAS, in a wonderful team at #ctglab in Amsterdam. Positions remain open until filled! https://twitter.com/DPosthu/status/1186645161272643586

    Reply on Twitter 1205089017492062208Retweet on Twitter 120508901749206220827Like on Twitter 120508901749206220829Twitter 1205089017492062208
    Retweet on TwitterDr. Anna Docherty Retweeted
    JillHF_AFSPJill Harkavy-Friedman@JillHF_AFSP·
    6 Dec

    Join me! I’m officially registered to walk in my 7th Out of the Darkness Overnight Walk. I’ll walk over 16 miles through the night in NYC to raise funds for AFSP and raise awareness for suicide prevention.https://www.theovernight.org/participant/Jill-Harkavy-Friedman #stopsuicide

    Reply on Twitter 1202965699628609537Retweet on Twitter 12029656996286095371Like on Twitter 120296569962860953719Twitter 1202965699628609537
    Retweet on TwitterDr. Anna Docherty Retweeted
    DPosthuDanielle@DPosthu·
    13 Nov

    We are still looking for several ambitious Postdocs, with knowledge of GWAS, statistics, scRNAseq, who want to work in our #CTGlab team @VUamsterdam, please retweet or apply! https://twitter.com/DPosthu/status/1186645161272643586

    Reply on Twitter 1194729213414260736Retweet on Twitter 119472921341426073640Like on Twitter 119472921341426073629Twitter 1194729213414260736
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    CONTACT

    Anna Docherty, Ph.D.
    383 Colorow Drive
    Salt Lake City, UT 84110

    Phone: 801.213.6905

    International Consortium for Schizotypy Research
    Learn about the International Consortium for Schizotypy Research.

    COLLABORATORS

    • Psychiatric Genomics Consortium
    • Stony Brook School of Medicine, HiTOP
    • Broad Institute, Stanley Center
    • Virginia Institute for Psychiatric and Behavioral Genetics
    • International Consortium on Schizotypy Research, 2017 Meeting

    OUR WORK IS SUPPORTED BY

    • Brain Behavior Research Foundation
    • National Institute of Mental Health
    • USTAR Center for Genetic Discovery
    • American Psychological Foundation
    • American Foundation for Suicide Prevention
    • University of Utah School of Medicine

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