It has become apparent that compiling data into a protected, relational database and crowdsourcing analytic and data science expertise will result in significant enhancement of current research on the structure and biological substrates of the psychosis spectrum.
Using low-coverage whole genome sequencing in the CONVERGE cohort (N = 10,640), we derived polygenic risk scores specific to each of over 300 molecular pathways previously shown to be relevant to severe psychopathology. We then identified gene pathways significantly predictive …
Fast PRS simulations allow us to select an optimal p-value threshold γ, perform more accurate power analyses, and estimate the polygenicity of a phenotype.
This research maps genetic risk for numerous health and psychiatric phenotypes to real-world outcomes and behaviors in emerging adults (N = 5,947) across ancestries.
Imputing genotype data from 4,800 completed suicide deaths and 3,500 ancestry-matched controls, we are able to conduct genome-wide association studies of completed suicide. These analyses also involve calculation of polygenic and methylation risk scores, and examine polygenic overlap of suicide …
This research leverages whole-genome sequencing in a large sample of autism pedigrees to predict clinical phenotypes using rare variants and polygenic risk profiles.